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Updates from the VertiGO! trial: latest developments from the research trial investigating the efficacy of the latest vestibular implant prototype

The VertiGO! trial is the most recent, currently active, trial performed by the Geneva-Maastricht group, investigating the new MED-EL vestibular implant prototype. This trial includes a total of eight participants.

Updates

• From July 2021, screening and inclusion of suitable candidates was started
• In October and December 2021, the first two participants were succesfully implanted with the new vestibular implant

Most recent publications on the vestibular implant published by the Geneva-Maastricht group

Click here for a list of all the publications by the Geneva-Maastricht group. See below for the most recent publications.

• Starkov D, Snelders M, Lucieer F, Janssen AML, Pleshkov M, Kingma H, van Rompaey V, Herssens N, Hallemans A, Vereeck L, McCrum C, Meijer K, Guinand N, Perez-Fornos A, van de Berg R. Bilateral vestibulopathy and age: experimental considerations for testing dynamic visual acuity on a treadmill. J Neurol. 2020 Dec;267(Suppl 1):265-272. doi: 10.1007/s00415-020-10249-z. Epub 2020 Oct 28. PMID: 33113022; PMCID: PMC7718189.
• Boutabla A, Cavuscens S, Ranieri M, Crétallaz C, Kingma H, van de Berg R, Guinand N, Pérez Fornos A. Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents. J Neurol. 2020 Aug 10. doi: 10.1007/s00415-020-10120-1. Epub ahead of print. PMID: 32778921.
• van de Berg R, Ramos A, van Rompaey V, Bisdorff A, Perez-Fornos A, Rubinstein JT, Phillips JO, Strupp M, Della Santina CC, Guinand N. The vestibular implant: Opinion statement on implantation criteria for research. J Vestib Res. 2020;30(3):213-223. doi: 10.3233/VES-200701. PMID: 32651339.
• Crétallaz C, Boutabla A, Cavuscens S, Ranieri M, Nguyen TAK, Kingma H, Van De Berg R, Guinand N, Pérez Fornos A. Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans. J Neural Eng. 2020 Jun 12;17(3):036027. doi: 10.1088/1741-2552/ab8342. PMID: 32213673.
• Stultiens JJA, Postma AA, Guinand N, Pérez Fornos A, Kingma H, van de Berg R. Vestibular Implantation and the Feasibility of Fluoroscopy-Guided Electrode Insertion. Otolaryngol Clin North Am. 2020 Feb;53(1):115-126. doi: 10.1016/j.otc.2019.09.006. Epub 2019 Oct 31. PMID: 31677739.
• Starkov D, Guinand N, Lucieer F, Ranieri M, Cavuscens S, Pleshkov M, Guyot JP, Kingma H, Ramat S, Perez-Fornos A, van de Berg R. Restoring the High-Frequency Dynamic Visual Acuity with a Vestibular Implant Prototype in Humans. Audiol Neurootol. 2020;25(1-2):91-95. doi: 10.1159/000503677. Epub 2019 Oct 29. PMID: 31661687.

Most recent publications on bilateral vestibular loss published by the Geneva-Maastricht group

• van Stiphout, L., Lucieer, F., Guinand, N., Pérez Fornos, A., van de Berg, M., Van Rompaey, V., Widdershoven, J., Kingma, H., Joore, M., & van de Berg, R. (2021). Bilateral vestibulopathy patients’ perspectives on vestibular implant treatment: a qualitative study. Journal of Neurology. https://doi.org/10.1007/s00415-021-10920-z
• van Stiphout, L., Lucieer, F., Pleshkov, M., Van Rompaey, V., Widdershoven, J., Guinand, N., Pérez Fornos, A., Kingma, H., & van de Berg, R. (2021). Bilateral vestibulopathy decreases self-motion perception. Journal of Neurology. https://doi.org/10.1007/s00415-021-10695-3
• Lucieer FMP, Van Hecke R, van Stiphout L, Duijn S, Perez-Fornos A, Guinand N, Van Rompaey V, Kingma H, Joore M, van de Berg R. Bilateral vestibulopathy: beyond imbalance and oscillopsia. J Neurol. 2020 Oct 8. doi: 10.1007/s00415-020-10243-5. Epub ahead of print. PMID: 33030608.
• Starkov D, Strupp M, Pleshkov M, Kingma H, van de Berg R. Diagnosing vestibular hypofunction: an update. J Neurol. 2020 Aug 7. doi: 10.1007/s00415-020-10139-4. Epub ahead of print. PMID: 32767115.
• van Dooren TS, Starkov D, Lucieer FMP, Vermorken B, Janssen AML, Guinand N, Pérez-Fornos A, Van Rompaey V, Kingma H, van de Berg R. Comparison of three video head impulse test systems for the diagnosis of bilateral vestibulopathy. J Neurol. 2020 Jul 27. doi: 10.1007/s00415-020-10060-w. Epub ahead of print. PMID: 32719974.
• Martin EC, Leue C, Delespaul P, Peeters F, Janssen AML, Lousberg R, Erdkamp A, van de Weijer S, Widdershoven J, Blom H, Bruintjes T, Zwergal A, Grill E, Guinand N, Perez-Fornos A, van de Berg MR, Stultiens JJA, Kingma H, van de Berg R. Introducing the DizzyQuest: an app-based diary for vestibular disorders. J Neurol. 2020 Jul 25. doi: 10.1007/s00415-020-10092-2. Epub ahead of print. PMID: 32712867.
• Herssens N, Verbecque E, McCrum C, Meijer K, van de Berg R, Saeys W, Vereeck L, Van Rompaey V, Hallemans A. A Systematic Review on Balance Performance in Patients With Bilateral Vestibulopathy. Phys Ther. 2020 Aug 31;100(9):1582-1594. doi: 10.1093/ptj/pzaa083. PMID: 32367131.
• Dobbels B, Lucieer F, Mertens G, Gilles A, Moyaert J, van de Heyning P, Guinand N, Pérez Fornos A, Herssens N, Hallemans A, Vereeck L, Vanderveken O, Van Rompaey V, van de Berg R. Prospective cohort study on the predictors of fall risk in 119 patients with bilateral vestibulopathy. PLoS One. 2020 Mar 9;15(3):e0228768. doi: 10.1371/journal.pone.0228768. PMID: 32150553; PMCID: PMC7062241.